Search results for "Neuroleptic drug"

Genetic polymorphisms of the dopamine D2 and D3 receptor and neuroleptic drug effects in schizophrenic patients

2001

Gender differences in the effects of haloperidol on avoidance conditioning in mice

1995

Abstract Gender differences in the effects of haloperidol (0.07S mg/kg per day for 5 days) on avoidance conditioning were evaluated. We also studied performance of the subjects free of the drug and the acute effects of haloperidol in animals trained without drug 48 h after the last haloperidol administration. Latencies of escape and avoidance responses, number of nonresponses, escapes, avoidances, crossings during the adaptation period, crossings during intertrial intervals, and total crossings per minute were analyzed. This dosage impaired conditioning of the male animals but did not attain the same effects on females. Haloperidol did not deteriorate performance of the task when it had bee…

Development of predictive retention-activity models of butyrophenones by biopartitioning micellar chromatography

2001

The predictive and interpretative capability of quantitative chromatographic retention-biological activity models is supported by the fact that in adequate experimental conditions the solute partitioning into the chromatographic system can emulate the solute partitioning into lipid bilayers of biological membranes, which is the basis of drug and metabolite uptake, passive transport across membranes and bioaccumulation. The use of retention data obtained in biopartitioning micellar chromatography (BMC) has been demonstrated to be helpful in describing the biological behaviour of different kinds of drugs. In this chromatographic system, polioxyethylene 23 lauryl ether Brij35 micellar mobile p…

Integrated Treatment Model for First-Contact Patients with a Schizophrenia-Type Psychosis: The Finnish API Project

1996

This paper presents the background, rationale, set-up and first results of the Finnish API study, whose aim was to investigate the use of a psychotherapeutically oriented and familycentred treatment model for acute psychosis in different treatment settings, and especially the role of neuroleptic drug treatment when working along the principles of the integrated treatment model. Six psychiatric catchment areas from different parts of the country participated by collecting a material of 136 first-contact patients with a schizophrenia-type psychosis. More than half of the patients received a formal diagnosis from the schizophrenia group at the initial examination, and more than one-third a dia…